![]() ![]() ![]() ![]() Clearly, there are abrupt fluctuations in early periods with ratios lower than 1while others with ratios higher than 1look sigmoid during increasing stage. Since k 1 and k 2 have to do with curve slopes, ratios of them are focused on (Figure 7a and b). Hence, we deduce that those fastidious bacteria are more likely to exhibit a LB-like growth curve because of better adaptation to additional factors. It is common knowledge that enrichment medium promotes metabolically fastidious organisms to grow with specific growth factors. Simulation of the binding between enzymes and polyPs in biosynthetic processġ)PolyPs with different lengths were docked to two phosphotransferases, PPK1 and PPK2B, to compare the binding behaviors and predicted binding energy of them.Ģ)Results guide how the project should be implemented with the best choice of the enzyme for polyP biosynthesis.Ī novel model for bacterial growth in synthetic wastewater (PA) mediumġ)Experimental data was used for curve fitting to test the model.Ģ)Fitting results validate that the plasmid design worked and the model will help lab members to predict bacterial growth.Ī great way to describe the relationships between polyP and gut bacteria based on computer programmingġ)Coefficients can be given by stochastic simulation based on programming.Ģ)Results can help predict the possible effect of polyP on gut bacteria community composition.Ī polyP-associated coherent feedforward loop for medicineġ)Simulative changes in concentrations of ions, active enzymes and stable polyP provide insight into transforming polyP into both IBD drugs and health products. You can choose the part you are most interested in. To make it convenient for readers, we provide an overview table to shed light on our Four-in Model. To make our novel models understood by everyone, we document our work in great detail, in which some stories and experience are shared. With the ambitious of exploiting modeling to guide, validate, clarify and expand our project, the MODEL group of Nanjing-China builds a Four-in Model: PolyP in Design, PolyP in Bacteria, PolyP in Gut and PolyP in Application, which covers molecular simulation, mathematic models and stochastic models. ![]()
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